The effects of saffron (Crocus sativus L.) in conjunction with concurrent training on body composition, glycaemic status, and inflammatory markers in obese men with type 2 diabetes mellitus: A randomized double‐blind clinical trial

摘要

Aims Chronic inflammation is one of the major challenges in the management of obesity and type 2 diabetes mellitus (T2DM). Our primary aim was to assess the anti‐inflammatory effects of Saffron (Crocus sativus L.) supplementation and concurrent training in obese men with T2DM. Methods Sixty obese men with T2DM (age?=?39?±?5?years; body mass?=?93.9?±?6?kg) were randomly assigned to four groups; concurrent training + placebo (CT; n?=?15), saffron supplementation (S; n?=?15), concurrent training + saffron supplementation (CTS; n?=?15), or control (CON; n?=?15). The participants in the CT group performed concurrent training (resistance + aerobic) three times per week for 12?weeks and received daily one pill of placebo (maltodextrin); the participants in the S group supplemented with one pill of 100?mg of saffron daily, and the participants in the CTS group participated in both saffron and training intervention while CON group continued regular lifestyle (no training and no supplementation). Inflammatory markers, body composition (evaluated by a multi‐frequency bioelectrical impedance device; Jawon X‐Contact 356), and metabolic profile were evaluated before and after interventions. Results All three interventions significantly (P?