New Coumarins from Roots and Fruit of Peucedanum morisonii

摘要

Chromatographic separation of constituents from roots and fruit of Peucedanum morisonii Besser (Apiaceae) isolated 30 compounds, including four new coumarins 1–4. UV and NMR spectroscopy and mass spectrometry established that the new compounds were officinalin isovalerate (1), umbelliferone-6-carboxylic acid 7-O-β-D-glucopyranoside (peumoriside I, 2), umbelliferone-6-carboxylic acid 7-O-(6′-O-β-D-apiofuranosyl)-β-D-glucopyranoside (peumoriside II, 3), and bergaptol 7-O-(6′-O-β-D-apiofuranosyl)-β-D-glucopyranoside (peumoriside III, 4). Glycosides 2 and 3 possessed inhibitory activity for cholinesterase, β-secretase 1, and monoamine oxidase.