Improved Labeling for “Transparent Mouse”

摘要

Techniques for clearing mouse tissues or whole bodies and making them transparent are useful for anatomic analysis, but labeling specific cell types has been difficult. Researchers have developed a method, called wildDISCO, to highlight these cells and improve visualization of structural details. The technique uses a solvent to remove cholesterol from cell membranes in the mouse's body and employs conventional antibodies to tag the cells.