Multifunctional hydrogel delivery system for disease therapy

摘要

Hydrogel have been widely applied in the field of tissue engineering and disease therapy, because hydrogel can not only regenerate and repair damaged tissues, but also avoid unnecessary side effects as well as enhance the accumulation at lesions. The function of hydrogel mainly depended on the property of basic polymer materials. The nature-like tissue and environment-friendly characteristics of hydrogel are widely applied in disease therapy. Therefore, hydrogel was carefully designed from these biocompatible polymer materials through covalent and noncovalent crosslinking, and can be recognized as suitable scaffolds for tissue repair and regeneration. The obtained hydrogel can promote the transport of nutrients and oxygen through interconnected macropores. In addition, the physical and chemical crosslinking versatility of hydrogel can not only enhance its mechanical strength and adhesive property, but also can be used as a reservoir to realize sustain-release of drugs. Moreover, hydrogel can fill the irregular lesions sites, promote wound healing and bear the high-frequency motion of the lesion sites. In this paper, we will summarize some biocompatible hydrogels for some primary disease treatment, and provide some inspiration for researchers to design suitable hydrogel, so as to overcome the limitations of current disease treatment and promote the clinical transformation of hydrogel.{GRAPHICAL ABSTRACT}