A scanning ion conductance microscope (SICM) has been developed, operating in several modes: DC mode, current modulation mode, and hopping mode. SICM employs a piezoelectric-inertial movement system. The nanoprobes, in the form of glass nanopipettes with an internal radius of r ～ 50 nm, have been created and tested. The current-voltage characteristics I (V) and current dependences on the distance between the probe and the sample I (z) (approach/withdrawal curves) were measured. Images of a polymeric test object with a periodic structure and a biological object (CHO cell) were obtained, their quality was assessed, and the features of the SICM operation in various modes are discussed. The multimode SICM provides non-destructive, non-contact visualization of soft objects in a liquid conducting medium with nanometer spatial resolution in various measuring modes and can be used in biology, cytology, electrochemistry, and medicine when studying inorganic soft objects, biological objects in buffer media, etc.
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机译：已经开发出一种扫描离子电导显微镜（SICM），它以多种模式工作：直流模式、电流调制模式和跳频模式。SICM采用压电惯性运动系统。已经创建并测试了内部半径为 r ~ 50 nm 的玻璃纳米移液器形式的纳米探针。测量电流-电压特性I（V）和电流对探头与样品I（z）之间距离的依赖性（接近/退出曲线）。获得了具有周期性结构的聚合物测试对象和生物对象（CHO单元）的图像，评估了它们的质量，并讨论了SICM在各种模式下的操作特征。多模SICM可在各种测量模式下以纳米空间分辨率对液体导电介质中的软物体进行无损、非接触式可视化，可用于生物学、细胞学、电化学和医学，用于研究无机软物体、缓冲介质中的生物物体等。
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