A novel approach for developing left bundle branch pacing and left bundle branch block in a canine model

摘要

Abstract Background and Objective Left bundle branch pacing (LBBP) has shown the benefits in the treatment of dyssynchronous heart failure (HF). The purpose of this study was to develop a novel approach for LBBP and left bundle branch block (LBBB) in a canine model. Methods A “triangle‐center” method by tricuspid valve annulus angiography for LBBP implantation was performed in 6 canines. A catheter was then applied for retrograde His potential recording and left bundle branch (LBB) ablation simultaneously. The conduction system was stained to verify the “triangle‐center” method for LBBP and assess the locations of the LBB ablation site in relation to the left septal fascicle (LSF). Results The mean LBB potential to ventricular interval and stimulus‐peak left ventricular activation time were 11.8?±?1.2 and 35.7?±?3.1?ms, respectively. The average intrinsic QRS duration was 44.7?±?4.7?ms. LBB ablation significantly prolonged the QRS duration (106.3?±?8.3?ms, p?