Rational Design of Heterocyclic Moieties Incorporated in 1,2,3Sugar-Triazole Derivatives for Antioxidant Studies

摘要

Reaction of heterocyclic azides with sugar alkyne under copper catalyzed 1,3-dipolar cycloaddition reaction resulted in the formation of triazoles in 64-90 of yield. Existence of beta-anomeric forms of sugar were identified from NMR spectral studies. The structures were confirmed by elemental analyses, spectrometry (H-1 C-13 NMR) analysis. Antioxidant activities of the synthesised sugar triazoles shows significant inhibition (89.2 ) at lower than 100 mu g/mL.