Narrative review of studies on HIV pre-exposure prophylaxis in Brazil and its implementation in the public health network

摘要

OBJECTIVES: To discuss studies conducted in Brazil relating to PrEP, from2012 to 2022, based on a narrative review. METHODOLOGY: The databasesof the Virtual Health Library/PAHO, portals from Scielo, Scopus, andPubMed, and the descriptors in English and Portuguese ‘Pre-exposureto HIV’ and ‘Brazil’ were used, as well as a list of planned/in-progressdemonstrative studies. Inclusion criteria consists of articles withfieldwork in Brazil coupled with PrEP in the Brazilian scenario; andarticles in English or Portuguese. Articles in which PrEP was not thecentral theme and the participating Brazilian population did not residein Brazil were excluded. RESULTS: 107 papers have been reviewed, 80articles met the inclusion criteria. The majority participating populationwas men who have sex with men. 61 studies preceded theimplementation of PrEP in Brazil. Studies carried out afterimplementation (n = 19) deal primarily with the impact of the COVID-19pandemic. CONCLUSIONS: There was an incipient number of studies onthe injectable form of PrEP. Fewer studies included segments withgreater difficulties in access, use, and adherence. Despite the issues thatcircumscribe this prevention technology, literature is consensual on theimportance of Brazilian leadership for implementing PrEP.