Creutzfeldt-Jakob Disease after Dental Procedure Along with the Initial Manifestations of Psychiatric Disorder: A Case Report

摘要

Introduction: Creutzfeldt-Jakob disease (CJD) as a prion disease is an untreatable type of progressiveneurodegenerative encephalopathy. Although no definitive case has been reported yet, here we report a case that giventhe history, course of symptoms, and recent dental practice, it is highly probable that it was caused by dental procedures.Case Report: The patient was a 52-year-old woman who has had memory problems gradually with forgetting the namesof family members since 6 weeks prior to the visit and shortly after the dental procedure. She experienced progressivevisual hallucinations accompanied by a sharp decline in cognitive, verbal, and motor abilities in just a few weeks. Finally,the diagnosis of Creutzfeldt-Jakob was made for her based on the clinical history and typical brain MRI.Discussion: Clinical evidence of this patient, along with positive brain MRI results, indicates the risk of prion transferthrough dental procedures. Paying attention to the neurological aspects of psychiatric manifestations and increasing theawareness of dentists about how to deal with and act on the potential dangers of prion transfer is of paramountimportance.