This study was intended to define T lymphocyte subsets in different clinical groups of COVID-19-infected patients to explore the interaction between T cell-mediated immune response and the severity of COVID-19 course. Lymphopenia in patients with severe COVID-19 was found. In patients with severe COVID-19 course, the absolute counts of CD3(+), CD4(+), and CD8(+) T lymphocytes at admission were lower than on day 14 after discharge. Further analysis showed that the older were the patients with COVID-19, the more likely they developed severe infection. The results confirmed the significance of T lymphocytes in the clearance of the COVID-19.
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机译:本研究旨在定义 COVID-19 感染患者不同临床组的 T 淋巴细胞亚群,以探索 T 细胞介导的免疫反应与 COVID-19 病程严重程度之间的相互作用。发现重症 COVID-19 患者的淋巴细胞减少。在重症 COVID-19 病程患者中,入院时 CD3(+)、CD4(+) 和 CD8(+) T 淋巴细胞的绝对计数低于出院后第 14 天。进一步的分析表明,COVID-19患者年龄越大,他们发生严重感染的可能性就越大。结果证实了 T 淋巴细胞在清除 COVID-19 中的重要性。
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