Comparison of Anti‐Human and Anti‐Porcine Factor VIII Inhibitor Levels in 63 Patients with Severe Haemophilia A

摘要

AbstractThe levels of anti‐human and anti‐porcine factor VIII inhibitors, measured in 63 severe haemophilia A patients, lay in the ranges of<0.2‐2,600 and<4.2‐1,300 Bethesda units per ml (BU/ml), respectively, with a median cross‐reactivity of 33%. In 4 patients, human and porcine inhibitor levels were determined using both plasma, either human or porcine, and factor VIII concentrate, either very high purity human or porcine (Hyate:C®). A good correlation between titres was found, whatever the source of factor VIII (plasma or concentrate). The cross‐reactivity varies from 0 to over 100%, indicating that the evaluation of both human and porcine inhibitors should be mandatory before any treatment with Hyate:C. Results show that of the 46 patients with human inhibitor of more than 5 BU/ml, 21 (46%) with a low porcine inhibitor (<5 BU/ml) could benefit