Lipid nanoparticles are a holistically superior formulation for dermal drug products, which combine effective drug delivery and skin carrying properties at the same time. Skin is a popular route for the delivery of locally and systemically acting drugs. Although the skin acts as a natural barrier against the penetration of foreign materials, opportunities exist for the delivery of therapeutic nanoparticles. Lipid nanoparticles (LNPs) are an attractive option for dermal drug delivery. Encapsulating lipophilic active ingredients within LNPs increases the stability of chemically labile active ingredients, and after skin application, LNP formulations form a lipid film known as an 'invisible patch', increasing skin hydration and improving dermal penetration. Many scientific studies have already proven the superiority of LNPs over classical skin formulations, such as emulsions or creams, or nanoemulsions. This drug delivery system is exploited in various cosmeceutical products, and has recently been described as the most successful carrier for skin delivery. But until now, there has been no proof-of-concept study to investigate if LNPs are indeed a holistically superior formulation principle when compared to other dermal drug delivery strategies.
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