Unconventional T cells shape tissue-specific lymph node responses

摘要

Lymphatic drainage from peripheral tissues to the lymph nodes carries tissue-specific information in the form of passively transported products and active transport by dendritic cells. In turn, this shapes the quantity and quality of the immune response in a tissue-specific manner. In addition, Ataideetal. now describe a role for lymphatic migration of unconventional T cells (UTCs) — gammadelta T cells, mucosal-associated invariant T(MAIT) cells and natural killer T (N KT) cells — in this process.