Bending oxygen saturation index and risk of worsening heart failure events in chronic heart failure

摘要

Aims Bendopnea is a clinical symptom of advanced heart failure with uncertain prognostic value. We aimed to evaluate whether bendopnea and the change in oxygen saturation when bending forward (bending oxygen saturation index [BOSI]) are associated with adverse outcomes in ambulatory chronic heart failure (CHF) patients. Methods and results We prospectively evaluated 440 subjects with symptomatic CHF. BOSI was defined as the difference between sitting and bending oxygen saturation (SpO(2)). The endpoint was the total number of worsening heart failure (WHF) events (heart failure hospitalization or urgent heart failure visit requiring parenteral diuretic therapy). The mean age was 74 +/- 10 years, 257 (58.6%) were male, and 226 (51.4%) had a left ventricular ejection fraction =-3%. The agreement between BOSI >=-3% and bendopnea was moderate (Gwet's AC 0.482, p =-3% showed an increased risk of WHF events (incidence rate ratio [IRR] 2.16, 95% confidence interval [CI] 1.67-2.79; p =-3% and not bendopnea was independently associated with an increased risk of total (first and recurrent) WHF episodes. Awareness of SpO(2) while assessing bendopnea may be a useful tool for predicting heart failure decompensations. [GRAPHICS] .