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>Bromodomain and extraterminal protein-targeted probe enables tumour visualisation in vivo using positron emission tomography
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Bromodomain and extraterminal protein-targeted probe enables tumour visualisation in vivo using positron emission tomography
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机译:Bromodomain and extraterminal protein-targeted probe enables tumour visualisation in vivo using positron emission tomography
Bromodomain and extraterminal (BET) proteins, a family of epigenetic regulators, have emerged as important oncology drug targets. BET proteins have not been targeted for molecular imaging of cancer. Here, we report the development of a novel molecule radiolabelled with positron emitting fluorine-18, [18F]BiPET-2, and its in vitro and preclinical evaluation in glioblastoma models.
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