Clinical Significance of a Circulating Tumor Cell-based Classifier in Stage IB Lung Adenocarcinoma A Multicenter, Cohort Study

摘要

Objective:To investigate the effectiveness of a CTC-based classifier in stratifying stage IB LUAD. Summary of Background Data:Stage IB LUADs have an approximately 70% 5-year survival rate. The clinical application of ACT is controversial due to inconsistent results in a series of trials and few useful guide biomarkers. Thus, there is a pressing need for robust biomarkers to stratify stage IB patients to define which group would most likely benefit from ACT. Methods: Two hundred twelve stage IB LUAD patients were enrolled and were divided into 3 independent cohorts. The aptamer-modified NanoVelcro system was used to enrich the CTCs. Results:A cutoff of 4 CTCs as the optimal prognostic threshold for stage IB LUAD was generated to stratify the patients in a 70-patient cohort into low-risk and high-risk groups. Patients with >= 4 CTCs in the training cohort had shorter progression-free survival (P 4 CTCs can define a high-risk subgroup, providing a new strategy to make optimal clinical decisions for stage IB LUAD.