Base Promoted Cascade Reaction: A Convenient Route to Hybrid S and N Polyheterocycles

摘要

abstract_textpBiologically privileged fused pyrimidine spirocycles were synthesized via a metal-free three-component cascade reaction utilizing mercapto/aza lactam active methylene compounds. This rapid and efficient one-pot operation quickly delivered seven different polycyclic and spirocyclic scaffolds such as pyranothiazolopyrimidine, benzothiazolopyranopyrimidine, pyranotriazolopyrimidine, benzoimidazolopyranopyrimidine, spiroindolinepyranothiazolopyrimidine, spirobenzothiazolopyranopyrimidineindoline, and spirobenzo-imidazolopyranopyrimidineindoline at room temperature with excellent regio/chemoselectivity./p/abstract_text