Multifunctional composite dressings based on Bletilla striata polysaccharide and zeolite for rapid hemostatic and accelerated wound healing

摘要

Abstract Zeolite powder has been used as the hemostatic material in both military and civilian areas. However, challenges remained for zeolite becoming an ideal wound dressing due to its limited bioactivity in wound recovery and lack of fixation. Based on the above problems, Bletilla striata polysaccharides (BSP)-based spongy dressings incorporated with zeolite were developed in this study. Spectral properties, surface morphology, physical properties, hemostatic performance, wound healing and histological analysis were conducted to investigate the composite dressings. The results showed that the composite dressings exhibited a significant effect in the hemostasis experiments in vivo and in vitro and could reduce the thermal effect caused by zeolite during hemostatic process. In addition, the composite dressings not only showed antibacterial activity, but also provided good wound healing performance by showing quick recover of wound after application, which was related to the BSP via regulatory of the inflammation. Our study suggested the potential of the developed composite dressing in the application of hemostatic and wound healing.Graphical abstract Illustration of preparing the BSP/zeolite composite dressing and its application to enhanced hemostasis, antibacterial and wound healing.