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Effects of incentivizing viral suppression in previously incarcerated adults living with HIV

机译:激励病毒抑制对既往被监禁的艾滋病毒感染者的影响

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Background: The amount of HIV in a person's blood can be suppressed to an undetectable level through antiretroviral therapy medications (ART). Adhering to an ART regimen can improve a person's health and reduce HIV transmission. Despite these benefits, many people with HIV do not maintain the level of adherence required to achieve an undetectable viral load. This problem is particularly common among people who have been incarcerated. Objective: To determine effects of incentivizing viral suppression in previously incarcerated adults with HIV. Methods: Adults with HIV (N = 102) and detectable viral load (>200 copies/mL) were randomly assigned to a Usual Care or Incentive group. Usual Care participants did not earn incentives for viral suppression. Incentive participants earned incentives ($10/day maximum) for providing blood samples with a reduced or undetectable (<200 copies/mL) viral load. Assessments were conducted every 3 months. Results collected during the first year were aggregated and compared based on group assignment and incarceration history. Results: Previously incarcerated participants in the Incentive group provided more (OR: 2.9; CI: 1.3-6.8; p <.05) blood samples with an undetectable viral load (69) than those in the Usual Care group (41). Never-incarcerated participants in the Incentive group provided more (OR: 6.8; CI: 2.2-21.0; p <.01) blood samples with an undetectable viral load (78) than those in the Usual Care group (36). Effects of incentives did not differ by incarceration history. Conclusions: Incentivizing viral suppression can increase viral suppression (undetectable viral load) in people who have been incarcerated.
机译:背景:通过抗逆转录病毒治疗药物(ART),可以将一个人血液中的HIV含量抑制到无法检测到的水平。坚持抗逆转录病毒治疗方案可以改善一个人的健康状况并减少艾滋病毒的传播。尽管有这些好处,但许多HIV感染者仍无法保持达到检测不到的病毒载量所需的依从性水平。这个问题在被监禁的人中尤为常见。目的:确定激励病毒抑制对既往被监禁的HIV感染者的效果。方法:将感染HIV(N=102)和可检测病毒载量(>200拷贝/mL)的成人随机分配到常规护理组或激励组。常规护理参与者没有获得病毒抑制的奖励。激励参与者因提供病毒载量降低或检测不到(<200 拷贝/mL)的血液样本而获得奖励(最高 10 美元/天)。评估每 3 个月进行一次。第一年收集的结果根据小组分配和监禁历史进行汇总和比较。结果:激励组中先前被监禁的参与者提供了更多(OR:2.9;置信区间:1.3-6.8;p <.05) 的血液样本检测不到病毒载量 (69%) 比常规护理组 (41%) 的血液样本。激励组中从未被监禁的参与者提供了更多(OR:6.8;置信区间:2.2-21.0;p <.01) 的血液样本检测不到病毒载量 (78%) 比常规护理组 (36%) 的血液样本。激励措施的效果不因监禁史而异。结论:激励病毒抑制可以增加被监禁者的病毒抑制(无法检测到的病毒载量)。

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