Abstract Lignin-loaded nanoparticles are versatile nanomaterials that may be used in wound healing properties. The current study describes a wound dressing formulation focused on Lignin-loaded dextran/glycol (DEX/GLY) nanoparticles. The Lignin-loaded dextran/glycol membranes were fabricated using Lignin solutions inside the dextran/glycol medium. The influence of various experimental conditions on dextran/glycol nanoparticle formations were examined. The sizes of dextran/glycol and Lignin-loaded dextran/glycol nanoparticles were examined through the HR-SEM. Moreover, the efficacy antibacterial activity of dextran/glycol and Lignin-loaded dextran/glycol nanoparticles was evaluated against the microorganisms gram-positive and negative. Furthermore, we observed the in vivo wound healing of wounds in skin using a mice model over a 14?days period. In this difference to the wounds of untreated mouse, quick healing was observed in the Lignin-loaded dextran/glycol nanoparticles-treated wounds with fewer injury. These results specify that Lignin-loaded dextran/glycol nanoparticles-based dressing material could be a ground-breaking nanomaterial having wound repair and implantations potential required for wound injury in anorectal surgery model, which was proven using an animal model.Graphic Abstract
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