It is common to characterize a single sample using multiple different microscopy methods that have variable scales, rotation and translation. Registering hyperspectral images of 2D materials is particularly difficult due to the lack of keypoints on un-patterned substrates. The strain/doping maps can assist by creating these keypoints. Registration of these images allow for multimodal analysis from these various instruments by aligning multiple images into a single coordinate space. This is done by Hough transformations and arbitrary resolution definitions to generate a new coordinate frame where spatial information may be preserved and correlated on a pixel by pixel basis.
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