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Modelling the association in bivariate survival data by using a Bernstein copula

机译:使用 Bernstein copula 对双变量生存数据中的关联进行建模

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Bivariate or multivariate survival data arise when a sample consists of clusters of two or more subjects which are correlated. This paper considers clustered bivariate survival data which is possibly censored. Two approaches are commonly used in modelling such type of correlated data: random effect models and marginal models. A random effect model includes a frailty model and assumes that subjects are independent within a cluster conditionally on a common non-negative random variable, the so-called frailty. In contrast, the marginal approach models the marginal distribution directly and then imposes a dependency structure through copula functions. In this manuscript, Bernstein copulas are used to account for the correlation in modelling bivariate survival data. A two-stage parametric estimation method is developed to estimate in the first stage the parameters in the marginal models and in the second stage the coefficients of the Bernstein polynomials in the association. Hereby we use a penalty parameter to make the fit desirably smooth. In this aspect linear constraints are introduced to ensure uniform univariate margins and we use quadratic programming to fit the model. We perform a Simulation study and illustrate the method on a real data set.
机译:当样本由两个或多个相关受试者的聚类组成时,就会出现双变量或多变量生存数据。本文考虑了可能被删失的聚类双变量生存数据。在对此类相关数据进行建模时,通常使用两种方法:随机效应模型和边际模型。随机效应模型包括一个脆弱模型,并假设受试者在一个共同的非负随机变量(即所谓的脆弱)上有条件地独立于聚类中。相比之下,边际方法直接对边际分布进行建模,然后通过 copula 函数强加依赖结构。在这篇手稿中,伯恩斯坦 copulas 用于解释双变量生存数据建模中的相关性。该文发展了一种两阶段参数估计方法,在第一阶段估计边际模型中的参数,在第二阶段估计关联中伯恩斯坦多项式的系数。因此,我们使用惩罚参数来使拟合尽可能平滑。在这方面,引入了线性约束以确保均匀的单变量裕量,我们使用二次规划来拟合模型。我们进行了仿真研究,并在真实数据集上说明了该方法。

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