The Outcome of Pregnancy in a Patient with Factor XII Deficiency: A Case Report

摘要

Factor XII (Hageman Factor) is a plasma serine protease known to be involved in triggering the intrinsic cascade pathway blood coagulation [1]. Factor XII deficiency is a rare genetic blood disorder that causes prolonged clotting of blood in vivo without the presence of protracted clinical bleeding or clotting tendencies. It is passed on by autosomal recessive inheritance [2]. It affects only 1 in 1 million individuals. Factor XII levels are lower in patients of Asian descent than in other ethnic groups [3]. Given the rarity of the disease, there has been no documentation on the incidence and prevalence of Factor XII deficiency in Malaysia.