Effects of aerobic exercise and resveratrol on adipocytokines in rats with nonalcoholic fatty liver disease

摘要

? 2022 Elsevier Masson SASBackground and aims: The aim of this study was to explore the effects of 6-week aerobic exercise alone, resveratrol alone, and combined aerobic exercise and resveratrol intervention on a non-alcoholic fatty liver rat model. In order to explore an ideal way to improve the effect of treating NAFLD, and to provide a certain theoretical basis for the future outcome of NAFLD and the setting of exercise prescriptions. Methods: To this aim thirty male Sprague Dawley rats were randomly divided into 5 groups: Control, NAFLD, N + E, N + R, N + E + R. NAFLD model was established by feeding high-fat diet for 16 weeks. After successful modeling, the exercise group used treadmill exercise for 6 weeks of aerobic exercise intervention, and the resveratrol group was gavaged for 6 weeks (dose: 40 mg/kg). After the experiment, it was marked by group number. The blood indicators of the rats were measured: TG, TC, FFA, GLU, LDL-c, HDL-c, ALT, AST, adiponectin, leptin. Take the liver tissue and divide it into five parts, each wrapped in tin foil and put into liquid nitrogen to be tested for TNF-α and IL-6 according to the group mark. Results: After successful modeling, compared with the control group, the levels of TG, TC, FFA, LDL-c, ALT, AST and GLU in NAFLD group were increased (P < 0.01, P < 0.01, P < 0.01, P < 0.01, P < 0.01, P < 0.01, P < 0.05), the level of HDL-c decreased (P < 0.05); TNF-α and IL-6 increased significantly (P < 0.01), and adiponectin decreased significantly (P < 0.01). After 6 weeks of different interventions, compared with NAFLD group, TG, FFA, ALT, AST and GLU of intervention group decreased significantly, HDL-c increased (P < 0.05), while the level of TC in N + R group and the level of LDL-c in N + E group also decreased but there was no significant change. Moreover, compared with NAFLD group, leptin (P < 0.01, P < 0.01, P < 0.05), TNF-α (P < 0.05, P < 0.05, P < 0.01) and IL-6 (P < 0.01, P < 0.05, P < 0.01) of intervention group were all significantly decreased, and adiponectin was significantly increased (P < 0.01). Conclusion: Either aerobic exercise or resveratrol alone have different improvement on glucose, lipid metabolism disorders and adipocytokine disorders in NAFLD rats. But the improvements are greatest with combined aerobic exercise and resveratrol intervention. It has a certain promotion effect on the outcome of NAFLD rats.