Gestational trophoblastic disease is a group of diseases that most commonly involve hydatidiform moles. Molar pregnancy is classified as complete or partial depending on histology and chromosomal pattern. Although benign, moles are considered premalignant because they have the potential to invade and metastasize. Malignancy developing after a molar pregnancy, the most common form of gestational trophoblastic neoplasia, has an excellent prognosis and is typically cured with single-agent chemotherapy. Although the International Federation of Gynecol-ogy and Obstetrics (FIGO) has established very clear human chorionic gonadotropin (hCG) parameters for the diagnosis of postmolar gestational trophoblastic neoplasia, the frequency and duration of hCG surveillance after molar evacuation remains debated.
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