Enhancement on physical, chemical, and biological properties of HNT-PVA-ALG-HAp biocomposite coating on implant substrate for biomedical application

摘要

? 2022Bone tissue engineering (BTE) is an attractive field of research because there has been significant growth in the number of orthopedic diseases and injuries over the past several years. Biomaterial device-related infections are considered as one of the most important concerns in total dental and orthopedic prostheses. In this situation, the successful instant enactment of titanium (Ti6Al4V) and its alloys served as prosthetic devices have been a motivation for the improvement of long-time implant biomedical applications. However, successful adaptation of these implant substrates remains a significant challenge on the safety issue. The objective of this study is to observe the bone formation and osseointegration in different composite-coated implant surfaces. In this study, the electrophoretic technique was used to coat different composites on Ti–6Al–4V alloy implants. The physicochemical properties and structural-relationships of the biocomposite coatings were investigated by using various characterization techniques, such as FTIR, XRD, SEM with EDAX, HR-TEM with EDAX and biological assays (Apoptotic assay by Acridine orange staining). From the results, the developed HNT-PVA-ALG-HAp biocomposite coating has enhanced the mechanical as well as biological properties.