Synthesis, NMR Spectroscopic Study of alpha-, beta- and gamma-Cyclodextrin Inclusion Complexes of 2-Deoxyecdysone and Their Anti-inflammatory Activity

摘要

2-Deoxyecdysone-3 beta,14 alpha,22R,25-tetrahydroxy-5 beta(H)-cholest-7-ene-6-one has been isolated from Silene wolgensis (Hornem) Bess. ex. Spreng. of Caryophyllaceae Juss. family for the first time. The complex formation of phytoecdysteroid with alpha-, beta- and gamma-cyclodextrins has been studied by NMR spectroscopy. Based on the change in the chemical shifts of protons of substrate and receptors, it has been established that 2-deoxyecdysone interacts with alpha-, beta- and gamma-cyclodextrins with formation of supramolecular inclusion complexes of 1:1 stoichiometric ratio with the entry of ring A of the steroid nucleus of the substrate molecule into the internal cavity of the receptor. Anti-inflammatory activity of the complexes has been studied.