Owing to the multifactorial pathological conditions management of obesity is a challenging problem. Finding an effective and safe remedy is a huge area of interest for many scientists and healthcare professionals in the field of biomedicine. There is a traditional claim that fresh cow urine and its distillate have anti-obesity activity. The present study aimed to assess the bioactive fraction of distillated cow urine having anti-obesity potential. Distilled cow urine was extracted by liquid-liquid extraction method using different solvents. Distilled cow urine and all the fractions were assessed for the anti-obesity activity by analysing non-invasive parameters. The distilled cow urine and it’s methanolic as well as butanolic fractions show significant anti-obesity potential. It has been found that body weight reduced without affecting food consumption. This effect was probably due to the reduction in dietary fat absorption by reducing the pancreatic lipase activity and enhancing its excretion in faeces. Further research is required to explore the exact mechanism of action.
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