Nitroglycerine (NG) has been used in the manufacture of explosives for over 100 years and ethylene glycol dinitrate (EGDN), a commonly used synonym being nitroglycol, for over 50 years. The acute effects of exposure to these two substances are well known. The possible long-term effects have been the subject of debate for many years but only recently has a definitive study indicated an excess of deaths from cardiovascular disease and cerebrovascular disease in exposed workers.A cohort of male employees in an explosives factory was defined, some of whom had had exposure to NG and EGDN. Observance of mortality experience over 16 years revealed an excess of deaths from acute myocardial infarction in the younger group of workers exposed to both substances.
展开▼
