Five ferrets of each sex were each inoculated with 15 third‐stage infective larvae ofDirofilaria immitisto study radiographic and angiographic changes in the cardiopulmonary system following heartworm infection; 5 additional ferrets of each sex served as noninfected controls. Prior to inoculation and every 8 weeks thereafter until 40 weeks, the infected and noninfected ferrets were radiographed; angiographic examinations were done prior to necropsy. At necropsy, the worms in the heart, lungs, and associated vessels were counted, and lung histosections were prepared and examined for changes. Radiographic changes were seen in the right side of the heart and associated vessels of infected ferrets as compared with the noninfected ferrets, but changes were less prominent than those seen in heartworm‐infected dogs and cats. The changes were primarily an increase in the size of the right side of the heart, especially the right atrium. Radiographically, no changes could be visualized in the pulmonary vascular system. Worms in the enlarged cranial vena cava, azygous vein, and left caudal lobar pulmonary artery of infected animals were delineated by angiography. Histologically, no changes were seen in the pulmonary vascular tiss
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机译:每性5只雪貂,各接种15只Dirofilaria immitis的第三期感染幼虫,研究心丝虫感染后心肺系统的影像学和血管造影变化;另外5只男女雪貂作为未感染的对照。接种前和接种后每 8 周至 40 周,对感染和未感染的雪貂进行 X 光检查;在尸检前进行血管造影检查。在尸检时,对心脏、肺和相关血管中的蠕虫进行计数,并准备肺组织切片并检查其变化。与未感染的雪貂相比,受感染的雪貂的心脏右侧和相关血管的影像学变化,但变化不如心丝虫感染的狗和猫明显。这些变化主要是心脏右侧的大小增加,尤其是右心房。在放射学上,肺血管系统没有变化。通过血管造影描绘感染动物扩大的颅腔静脉、合子静脉和左尾叶肺动脉中的蠕虫。在组织学上,肺血管炎未见变化
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