Raman spectroscopy is widely used in many applications - including biopharmaceutical manufacturing - that require analysis of the chemical composition of solid, liquid or gaseous materials. This non-destructive analytical technique can not only provide detailed information about the chemical structure, but also give insight into the phase and polymorphy, as well as crystallinity and molecular interactions. The drawback is that it often involves complex analytical workflows and requires the use of highly specialized equipment together with expert knowledge in Raman spectroscopy techniques. New technologies have been introduced to the market in recent years, making Raman technology more accessible to a wider public through analyzers with intuitive control and user-friendly interfaces. This article talks about the need for modern process analytical technologies that are accurate and reliable - while being more accessible to lab technicians - and how they can be used for biopharmaceutical process monitoring.
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