AbstractThe performance of a leukocyte reduction bedside filter with different types of RBC concentrates was analyzed. Three types of RBCs were prepared: buffy‐coat‐depleted RBCs suspended in saline‐adenine‐glucose‐mannitol (SAGM)‐additive solution (BC‐RBCs; n = 20), RBCs suspended in SAGM‐additive solution without buffy coat removal (SAGM‐RBCs; n = 20), and RBCs drawn in CPDA‐1 conservative solution and processed for component preparation by the platelet‐rich plasma method (CPDA‐RBCs; n = 20). The units were filtered within 8 h of collection. One filter was used for every 2 units. High numbers of residual WBCs were found even in the units filtered first. Filtration of CPDA‐RBCs resulted in a higher residual WBC content than SAGM‐RBCs or BC‐RBCs (p = 0.0032 and p = 0.0002, respectively). The filter performance strikingly decreased when the WBC load per filter exceeded 4 × 109or the platelet load was less than 100 × 109. We conclude that filter performance varies with the WBC and platelet content of the RBC concentrates. Under the experimental conditions assayed in this study CPDA‐RBCs are the least appropriate ones to be use
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