Synthesis, Characterization, and Anticancer Activity of Novel Imidazo1,2-apyridine Linked 1,2,3-Triazole Derivatives

摘要

A novel series of imidazo[1,2-a]pyridine linked 1,2,3-triazole derivatives has been designed, synthesized and the structures have been confirmed by H-1 and C-13 NMR and mass spectral analysis. The synthesized compounds have been evaluated for their in vitro cytotoxic activity against two cancer cell lines along with normal cell line (HEK293) by MTT assay. Among all the tested compounds, the derivative with 3-methoxypheny I moiety exhibits potent inhibitory activity against MCF-7 and Hela cell lines with IC50 values of 2.55 and 3.89 mu M respectively.