Introduction: The purpose is to compare posterior capsule opacification (PCO) and its impact on vision between Clareon CNA0T0 (Alcon) and Tecnis ZCB00 intraocular lenses (IOLs) (Johnson&Johnson) 1, 6, and 12 months after implantation. Methods: A prospective observational study was performed at the Nuestra Senora de Gracia Hospital (Zaragoza, Spain). Fifty eyes (50 patients) with Tecnis IOL (group 1) and 60 eyes (60 patients) with Clareon IOL (group 2) were enrolled. One, 6, and 12 months after age-related cataract surgery by five different surgeons, the following tests were performed: mesopic corrected distance visual acuity (CDVA), CSV1000-E test, KR-1W wavefront analyzer, OQAS II, Catquest-9SF questionnaire and mydriatic slit-lamp pictures. PCO intensity was quantified and the area of opacification was measured using ImageJ (NIH). Results: Mean age was 71.20 +/- 6.79 years in group 1, and 71.73 +/- 8.17 years in group 2 (p = 0.72); mean axial length was 23.46 +/- 1.14 and 23.53 +/- 0.91 mm, respectively (p = 0.72); mean IOL power was 21.69 +/- 2.26 D and 21.28 +/- 2.44 D, respectively (p = 0.37). One month after surgery there were differences in intensity of PCO (0.73 +/- 0.60 and 1.05 +/- 0.71, respectively, p = 0.02). Six months after surgery statistical differences were found in VA with 20% CS in mydriatic conditions (0.26 +/- 0.21 logMAR (20/36) and 0.18 +/- 0.17 logMAR (20/30), respectively, p = 0.04). Twelve months after surgery, no differences were detected between groups. As for the evolution of PCO within the Clareon group, high order aberrations (p < 0.05) and the Strehl ratio (p = 0.02) decreased. Conclusion: There are no differences in slit-lamp pictures or visual function between both IOLs during the first 12 months after implantation.
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