A 35-year-old man with generalized insults was admitted to the intensive care unit because of third-line treatment of persistent epileptic insults with antiepileptic drug therapy. Topiramate was added on top of his outpatient regimen in combination with intravenous antiepileptic drugs. Miscommunication and inappropriate topiramate dosing (2,500 mg twice) resulted in an acute topiramate intoxication. Toxicokinetic assessment showed toxic serum topiramate concentration of 55 mg/L and a dose-dependent shift of peak time t(max). According to our modulations, t(max) follows Y = 0.0009X + 2.65, where X is the topiramate dose. Our results have important implications for effectiveness of gut decontamination modalities.
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机译：一名 35 岁全身性侮辱男性因抗癫痫药物治疗持续性癫痫损伤的三线治疗而入住重症监护病房。托吡酯被添加到他的门诊治疗方案中，并联合静脉注射抗癫痫药物。沟通不畅和托吡酯剂量不当（2,500 mg，两次）导致急性托吡酯中毒。毒代动力学评估显示，血清毒性托吡酯浓度为55 mg/L，峰值时间t（max）呈剂量依赖性变化。根据我们的调制，t（max） 遵循 Y = 0.0009X + 2.65，其中 X 是托吡酯剂量。我们的研究结果对肠道去污方式的有效性具有重要意义。
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