Eosinophilic esophagitis (EoE) is a chronic, immune-mediated disease in which eosinophils accumulate in the esophagus, leading to inflammation and esophageal dysfunction. Commonly characterized by heartburn, chest or abdominal pain, dysphagia, difficulty eating, esophageal damage, and/or food impaction, EoE can mimic other gastrointestinal (GI) conditions involving elevated eosinophils in the esophagus (e.g., gastroesophageal reflux disease, inflammatory bowel disease, celiac disease). Appropriate diagnosis of EoE via upper endoscopy and esophageal-lining biopsy is essential to decrease eosinophil levels in the esophagus, prevent or minimize damage to esophageal tissue, and manage symptoms.
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