Gastrointestinal Tract Lymphomas A Review of the Most Commonly Encountered Lymphomas

摘要

center dot Context.-The gastrointestinal (GI) tract is the most common site of extranodal non-Hodgkin lymphoma, accounting for 20% to 40% of all extranodal lymphomas. The majority of these are systemic processes secondarily involving the GI tract. Primary GI lymphomas are less common, accounting for approximately 10% to 15% of all non-Hodgkin lymphomas. Most non-Hodgkin lymphomas involving the GI tract are of B-cell lineage, of which diffuse large B-cell lymphoma is the most common subtype, irrespective of location. Objective.-To review the lymphoproliferative neo-plasms of B-cell and T-cell lineage involving the luminal GI tract according to the most prevalent subtypes at each anatomic site. Data Source.-Systematic search of the PubMed data-base for updated literature on GI lymphoma epidemiology, subtypes, clinical, endoscopic, and genetic findings. Histologic images are derived from our collection of clinical cases. Conclusions.-The GI tract is the most common site of extranodal lymphoproliferative neoplasms. Recognition of the most frequently encountered GI lymphomas is imper-ative for patient management and treatment. (Arch Pathol Lab Med. 2021;145:1585-1596 ; doi: 10.5858/arpa.2020-0661-RA)