Gold Nanorods with Functionalized Organosilica Shells: Synthesis and Prospects of Application in Tumor Theranostics

摘要

The features of the formation of organosilica shells from gamma-mercaptopropyltrimethoxysilane on the surface of gold nanorods and the possibilities of using the prepared composite particles as means of combined tumor therapy are discussed. It is shown that the presence of SH functional groups, which are able to coordinate platinum ions, in the shells makes it possible to load rather large amounts of an anticancer drug, cisplatin, into them. Quantitative data are obtained on the regularities of the sorption of this drug and the influence of the pH and ionic strength of a solution on the kinetics of its desorption.