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Impact of new gestational diabetes mellitus criteria on stillbirth: A regional population-based study in Japan

机译:新的妊娠糖尿病标准对死产的影响:日本的一项基于人群的区域研究

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Aim: The aim of this study was to determine whether the new gestational diabetes mellitus (GDM) criteria increase the prevalence of diabetes-mellitus- related stillbirths by using a regional population-based approach. Material and Methods: A retrospective, population-based study was conducted to assess 114 036 deliveries from 2000 to 2010 in Miyazaki, Japan. During this period 318 stillbirths occurred after 22 weeks of gestation. Of these cases, 236 were examined to determine the cause of death. The remaining 82 cases were not fully investigated. In particular, we investigated the prevalence of pregestational diabetes mellitus and GDM among the stillbirths. We also applied new GDM criteria to evaluate the impact of these factors on stillbirth. Results: Of the 236 stillbirths, 47 were due to an explainable cause. Application of previous criteria indicated two cases of pregestational diabetes mellitus and three GDM cases in the remaining unexplained stillbirths. By applying new GDM criteria, the GDM count increased to 17. Conclusions: In an unselected population in southern Japan, the application of new GDM criteria resulted in a 5.7-fold increase (from 2.4 3/126 to 13.5 17/126) in the number of GDM cases in unexplained stillbirths. Even in women with a mild degree of GDM, proper management of both mother and fetus could reduce the number of unexplained stillbirths.
机译:目的:本研究的目的是通过使用基于区域人群的方法确定新的妊娠糖尿病 (GDM) 标准是否会增加糖尿病相关死产的患病率。材料和方法:进行了一项基于人群的回顾性研究,以评估 2000 年至 2010 年在日本宫崎的 114 036 例分娩。在此期间,妊娠 22 周后发生了 318 例死产。在这些病例中,有236例被检查以确定死因。其余82起案件没有得到充分调查。特别是,我们调查了死产中孕前糖尿病和GDM的患病率。我们还应用了新的GDM标准来评估这些因素对死产的影响。结果:在 236 例死产中,47% 是由可解释的原因引起的。先前标准的应用表明,在其余不明原因的死产中,有2例孕前糖尿病和3例GDM病例。通过应用新的 GDM 标准,GDM 计数增加到 17 个。结论:在日本南部一个未选择的人群中,应用新的GDM标准导致不明原因死产的GDM病例数量增加了5.7倍(从2.4%[3/126]增加到13.5%[17/126])。即使在轻度GDM的女性中,对母亲和胎儿的适当管理也可以减少不明原因的死产数量。

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