AbstractThe authors have investigated in the component parts of the uterine corpus of the C3H/N mouse the distribution pattern of 15 enzymes, some of them for the first time. In the endometrial epithelium alkaline and acid phosphatase, 5‐nucleotidase, adenosinetriphosphatase, β‐glucuronidase, NADD, NADPD, and the dehydrogenases studied, were found to show cyclical variations in intensity and localization which parallel the estrogen impregnation of the animal. Cyclical variations in intensity were found in the endometrial stroma for the activity of alkaline phosphatase, adenosinetriphosphatase, and β‐glucuronidase. Analogous variations in the myometrium are reported for alkaline phosphatase and β‐glucuronidase. A relationship between the functional activity of fibroblasts and the intensity of the activity of alkaline phosphatase is suspected in the subepithelial connective tissue. Macrophages show activity of a variety of enzyme systems. Their high acid phosphatase activity is to be attributed to storage of organic substances deriving from the breakdown of the endometrial epithelium. A similar relationship between enzyme activity and storage function is suspected for β‐glucuronidase. The sudden increase in the aminopeptidase activity in the endometrial epithelium and stroma at the end of the estrous cycle may be the expression of the intense catabolic phenomena which characteri
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