Albuminuria increased the risk of left ventricular hypertrophy in type 2 diabetes patients with early renal insufficiency

摘要

Aim Albuminuria and left ventricular hypertrophy are important predictors of cardiovascular disease. We speculated that albuminuria increases the risk of left ventricular hypertrophy in patients with type 2 diabetes and early renal impairment. Methods A total of 330 patients with type 2 diabetes and early renal insufficiency were recruited and classified according to albuminuria level (normal albuminuria, microalbuminuria, and macroalbuminuria). Plasma glucose, glycated hemoglobin (HbA1c), creatinine, uric acid, fasting insulin, albuminuria/urine creatinine ratio, renal function, insulin sensitivity, visceral fat index, body mass index, blood pressure, and left ventricular mass were assessed. The relationship between albuminuria and left ventricular hypertrophy was examined using logistic regression analysis and multiple linear regression. Results The risk of left ventricular hypertrophy was higher in the microalbuminuria group (odds ratio [OR] 14.602, 95% confidence interval [CI] 7.050-30.243) and macroalbuminuria group (OR 21.455, 95% CI 8.613-53.443) than in the normal albuminuria group. Conclusions Albuminuria increases the risk of left ventricular hypertrophy in patients with type 2 diabetes and early renal insufficiency.