Highly Scalable, Wearable Surface-Enhanced Raman Spectroscopy

摘要

The last two decades have witnessed a dramatic growth of wearable sensortechnology, mainly represented by flexible, stretchable, on-skin electronicsensors that provide rich information of the wearer’s health conditionsand surroundings. A recent breakthrough in the field is the development ofwearable chemical sensors based on surface-enhanced Raman spectroscopy(SERS) that can detect molecular fingerprints universally, sensitively, andnoninvasively. However, while their sensing properties are excellent, thesesensors are not scalable for widespread use beyond small-scale humanhealth monitoring due to their cumbersome fabrication process and limitedmultifunctional sensing capabilities. Here, a highly scalable, wearable SERSsensor is demonstrated based on an easy-to-fabricate, low-cost, ultrathin,flexible, stretchable, adhesive, and biointegratable gold nanomesh. It can befabricated in any shape and worn on virtually any surface for label-free, largescale,in situ sensing of diverse analytes from low to high concentrations(10–10~6 × 10~(?9)m). To show the practical utility of the wearable SERS sensor,the sensor is tested for the detection of sweat biomarkers, drugs of abuse,and microplastics. This wearable SERS sensor represents a significant steptoward the generalizability and practicality of wearable sensing technology.