Glycemic Variability Within 1 Year Following Surgery for Stage II-III Colon Cancer

摘要

Objective: To examine glycemic variability within 1 month and 1 year following surgery among adult patients, with and without Type 2 Diabetes (T2D), treated for stage II-III colon cancer. Method: A retrospective analysis of electronic health record data was conducted. Glycemic variability (i.e., standard deviation SD and coefficient of variation CV of > 2 blood glucose measures) was assessed within 1 month and within 1 year following colon surgery. Chi-square (chi(2)), Fisher's exact, and Mann-Whitney U tests were used for the analyses. Results: Among the sample of 165 patients with stage II-III colon cancer, those with T2D had higher glycemic variability compared to patients without T2D (p < .001), with values within 1 month following surgery (SD = 44.69 mg/dL, CV = 27.4) vs (SD = 20.55 mg/dL, CV = 17.53); and within 1 year following surgery (SD = 45.04 mg/dL, CV = 29.04) vs (SD = 21.36 mg/dL, CV = 18.6). Associations were found between lower body mass index and higher glycemic variability (i.e., SD r = -.413, p < .05 and CV r = -.481, p < .01) within 1 month following surgery in patients with T2D. Higher preoperative glucose was associated with higher glycemic variability (i.e., SD r = .448, p < .01) within 1 year in patients with T2D. Demographic and clinical characteristics were weakly associated with glycemic variability in patients without T2D. Conclusions: Patients with stage II-III colon cancer with T2D experienced higher glycemic variability within 1 month and within 1 year following surgery compared to those without T2D. Associations between glycemic variability and demographic and clinical characteristics differed by T2D status. Further research in prospective studies is warranted.