Modification of metal-organic frameworks Zn(BDC) with 8-hydroquinoline and their application in lymph node imaging in vivo

摘要

The large surface area and porous structure of MOF materials could provide binding sites for fluorescent moieties for bioimaging. Herein, we reported the preparation of fluorescent MOF material Zn(BDC) by 8-hydroquinoline modification [Zn(BDC)-8HQ]. Zn(BDC)-8HQ emitted strong fluorescence at 507 nm. The fluorescent Zn(BDC)8HQ had a hydrodynamic radius of 255 nm, suitable for lymph node tracing. After subcutaneous injection, a bright spot could be distinguished at the injection site. The injections to front extremities resulted in sentinel lymph node accumulations. The low toxicity of Zn(BDC)-8HQ was evidenced by serum biochemical index and histopathological observations.