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机译:A semi‐mechanistic dose‐finding design in oncology using pharmacokinetic/pharmacodynamic modeling
PlayStation;
Department of Biostatistics,The University of Texas MD Anderson Cancer Center;
Department of Mathematics,The University of Texas at AustinBiostatistics Department,St. Jude Children's Research Hospital;
area under the concentration‐time curve (AUC); dose response; maximum tolerated dose; pharmacologic effect; phase I trial; toxicity;