Filling the gap between the heart and the body in acromegaly: a case-control study

摘要

Abstract Objective Cardiovascul diseases are the most common comorbidities in acromegaly. Potential parameters in pathology of cardiovascular comorbidities are changes in levels of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) as well as body composition parameters.Purpose The aim of this study was to examine morphological and functional parameters of the cardiovascular system by echocardiography and to assess its relationship with disease activity and body composition parameters.Methods We prospectively enroled 129 acromegalic patients (82 females, 47 males) and 80 healthy controls (53 females, 27 males) matched for age, gender, and BMI. All patients underwent two-dimensional echocardiography. Body composition parameters were assessed by dual-energy X-ray absorptiometry.Results Acromegaly patients presented with higher left ventricle mass (LVM) compared to controls (LVMI: 123?±?45?g/m2 vs 83?±?16?g/m2, P?