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Low prevalence and disease severity of COVID-19 in post-liver transplant recipients-A single centre experience

机译:肝移植后受者 COVID-19 的患病率和疾病严重程度低-单一中心经验

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Coronavirus disease 2019 (COVID-19) caused by a novel coronavirus called severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is driving a present day global pandemic. Immunosuppressed patients are regarded as a high-risk cohort. The following is a short report on COVID-19 in liver transplant recipients (n = 5) from a high volume UK liver transplant unit with a large follow-up cohort (n = 4500). Based on this limited data, liver transplant recipients appear to have a low incidence of COVID-19, with less severe symptoms than expected, when compared with the general population and other solid organ recipients. This possibly could be related to self-isolation adherence and/or the 'ideal' level of immunosuppression that favourably modulates the immune response to COVID-19.
机译:2019 年冠状病毒病 (COVID-19) 由一种称为严重急性呼吸系统综合症冠状病毒 2 (SARS-CoV-2) 的新型冠状病毒引起,正在推动当今的全球大流行。免疫抑制患者被视为高危人群。以下是来自英国大容量肝移植病房的肝移植受者 (n = 5) 中 COVID-19 的简短报告,该病房具有大型随访队列 (n = 4500)。基于这些有限的数据,与普通人群和其他实体器官受者相比,肝移植受者的 COVID-19 发病率似乎较低,症状比预期的要轻。这可能与自我隔离依从性和/或有利于调节对 COVID-19 的免疫反应的“理想”免疫抑制水平有关。

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