A NIR-Ⅱ Fluorescent PolyBodipy Delivering Cationic Pt-NHC with Type Ⅱ Immunogenic Cell Death for Combined Chemotherapy and Photodynamic Immunotherapy

摘要

Tumor immunotherapy has emerged as one of the most promising clinicaltechniques to treat cancer tumors. Despite its clinical application, thecancerous immunosuppressive microenvironment limits the therapeuticefficiency of the treatment. To generate a stronger immunogenic therapeuticeffect, herein, a platinum complex for chemotherapy and a BODIPY photosensitizerfor photodynamic therapy are encapsulated into multimodal type Ⅱimmunogenic cell death (ICD) induce nanoparticles. As the platinum complexand the photosensitizer are able to induce type Ⅱ ICD, an exceptionally strongimmune response is observed in triple-negative breast cancer cells. Whileremaining stable and therefore poorly cytotoxic in the dark, the nanomaterialis found to quickly dissociate upon exposure to near-infrared light, causinga multimodal mechanism of action in cancer cells as well as multicellulartumor spheroids through combined chemotherapy, photodynamic therapy,and immunotherapy. The nanoparticles are found to nearly fully eradicatea triple-negative breast cancer tumor and therefore to strongly enhance thesurvival of tumor-bearing mice models using low drug and light doses.