Unconventional T cell subsets, including donor-unrestricted T cells (DURTs) and gamma delta T cells, are promising new players in the treatment and prevention of infectious diseases. In this issue of the JCI, Ogongo et al. used T cell receptor (TCR) sequencing to characterize unconventional T cell subsets in surgical lung resections and blood from Mycobacterium tuberculosis-infected (Mtb-infected) individuals with and without HIV coinfection. The study revealed highly localized expansions of gamma delta T cell clonotypes not previously associated with the immune response to Mtb and demonstrates the power of high-throughput analysis of the TCR repertoire directly from infected tissue. The findings contribute to our understanding of tuberculosis control and have implications for the development of both therapeutic and vaccination strategies.
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机译:非常规T细胞亚群,包括供体非限制性T细胞(DURT)和γ-δ-T细胞,在治疗和预防传染病方面是有希望的新参与者。在本期JCI中,Ogongo等人使用T细胞受体(TCR)测序来表征手术肺切除术中的非常规T细胞亚群和结核分枝杆菌感染(Mtb感染)的个体的血液,无论是否合并HIV感染。该研究揭示了以前与 Mtb 免疫反应无关的 γ δ T 细胞克隆型的高度局部扩增,并证明了直接从感染组织中对 TCR 库进行高通量分析的能力。这些发现有助于我们对结核病控制的理解,并对治疗和疫苗接种策略的制定具有重要意义。
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