Hyperspectral imaging (HSI), a widely used biosensing technique, has been applied to tumor detection. Rapid, accurate, and low-cost detection of blood cancer using hyperspectral technology remains a challenge. We developed a new method to discriminate blood cancer using hyperspectral imaging (HSI) and the forward searching method (FSM). Four commonly used classification models are applied for four types of blood cancer spectra recognition. The support vector machine (SVM) model with the highest recognition accuracy (94.5%) combined with HSI achieves high-precision tumor identification. For higher recognition accuracy and lower hardware barriers, based on the selection probabilities of spectral lines calculated by a multi-objective atomic orbital search method, the FSM is proposed for HSI feature selection. With the proposed method, the wavelength band range of the spectrum is reduced by at least 50%. Compared with the traditional dimensionality reduction methods, the FSM can obtain a higher accuracy rate with lower hardware requirements. These results show that our proposed method can achieve non-invasive rapid screening of blood cancers with lower hardware requirements. Therefore, HSI assisted with FSM and SVM hybrid models can be a powerful and promising tool for blood cancer detection.
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